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A detailed analysis of high-resolution structural data and computationally predicted dynamics was carried out for a designed sugar-binding protein. Micro-determination of plasma diphenylhydantoin by gas-liquid chromatography. The subjects were 64 patients undergoing PVP (PVP group) and 67 undergoing vertebral perforation (perforation group). The hypothesis that a C-S-lyase-mediated final metabolism of paracetamol-S conjugates in the kidney might be responsible for nephrotoxicity needs support by further experimental investigations.

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